SSL (secure socket layer protocol), currently using TLS 1.2 or greater encryption, is used to secure transmissions between servers and clients. Example: Visiting a https address from Google Chrome or Safari. SSL / TLS certificates allow clients to verify a server's authenticity against known Certificate Authorities before establishing an encrypted connection. This helps determine if the server is who they say they are.

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Symantec Endpoint Protection (SEP) is provided free of charge to UCSF faculty, staff, learners and researchers. SEP is designed to (1) detect, remove and prevent the spread of viruses, spyware and other security risks and (2)​​​ provide Windows, Mac and Linux computers with anti-virus (AV) and anti-spyware protection. In addition, UCSF SEP clients automatically keep both the client software and security definitions (AV and IPS) updated for the most complete protection.

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